Factors Predicting the Need for Re-treatment After Laser Refractive Surgery in Patients With Mixed Astigmatism

PURPOSE: To identify risk factors that increase the likelihood of re -treatment following refractive surgery in patients with mixed astigmatism. METHODS: This was a retrospective study including patients who underwent either laser in situ keratomileusis (LASIK) or photorefractive keratectomy (PRK) between 2000 and 2019 and had mixed astigmatism (spherical error of +0.50 D or greater and spherical equivalent of less than 0.00 diopters [D]). Patients were divided into two groups according to whether they underwent re -treatments during the study period. RESULTS: Overall, 785 eyes (785 patients) were included. In total, 5.2% of the eyes (n = 41) underwent re -treatment. The re -treatment group was more likely to have preoperative high astigmatism (80.5% vs 48.3%, P < .001), moderate to high hyperopia (36.6% vs 22.3%, P = .035), and to have undergone surgery earlier during the study period (P < .001). They were also more likely to have undergone surgery using the WaveLight EX200 rather than the EX500 laser platform (Alcon Laboratories, Inc) (P < .001), have a treated optical zone of 6 mm rather than 6.5 mm (P < .001 for both), and their maximum ablation depth was greater (P < .001). There was no difference between the re -treatment and control groups regarding procedure type (PRK vs LASIK). Binary logistic regression found preoperative high astigmatism (odds ratio = 3.97, P < .001) and the type of laser platform used (EX200, odds ratio = 7.78, P < .001) as the only independent factors associated with re -treatment. CONCLUSIONS: Re -treatment rates following correction of mixed astigmatism were 5.2% over 20 years. Use of a sixthgeneration laser platform significantly reduced the risk of re -treatment. Presence of high astigmatism is a significant risk factor for re -treatment. There was no difference in retreatment risk between PRK and LASIK. [J Refract Surg. 2024;40(2):e73 -e78.]