Comparative Analysis of Allogeneic Bone Marrow Transplantation Outcomes Between Japanese and Non-Japanese Populations
Transplantation proceedings(2024)
摘要
Background. As the Japanese population may have less genetic diversity than other ethnic groups, treatment outcomes may be affected when allogeneic hematopoietic cell transplantation is performed in other races. However, evidence explaining the effect of racial differences is limited. Methods. We used the Japanese National Database to examine the outcomes of first allogeneic bone marrow transplantations (BMTs) performed between Japanese and non -Japanese patients from 1996 to 2021. We performed propensity score matching using sex, age group, underlying disease group, HLA mismatch, conditioning regimen intensity, and BMT implementation age to select Japanese -to -Japanese BMT patients as the controls. Results. The numbers of non -Japanese -to -Japanese and Japanese -to -non -Japanese BMT cases included in the analysis were 48 and 75, respectively, and the following outcomes were compared: overall survival, non -relapse mortality, acute graft -vs -host disease (GVHD) >= grade II, chronic GVHD, and engraftment of neutrophils and platelets. Most parameters did not differ when comparing BMTs according to ethnicity; only platelet engraftment was delayed in Japanese -to -non -Japanese BMT but not in non -Japanese -to -Japanese BMT. Conclusions. The results of this study suggested that BMT performed in Japanese and nonJapanese patients has little effect on treatment outcomes. The results of this study may be useful for donor selection in Japan, where internationalization has progressed in recent years.
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