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A smart cysteine-activated and heavy-atom-free nano-photosensitizer for photodynamic therapy to treat cancers.

Shengze Su,Xingcan Li,Qian An,Tao Liang,Yanying Wang,Hongping Deng,Xiaoxing Xiong,Wing-Leung Wong,Huijuan Zhang,Chunya Li

Chemical communications (Cambridge, England)（2024）

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Abstract
A smart and heavy-atom-free photoinactive nano-photosensitizer capable of being activated by cysteine at the tumor site to generate highly photoactive nano-photosensitizers that show strong NIR absorption and fluorescence with a good singlet oxygen quantum yield (16.8%) for photodynamic therapy is reported.
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