The impact of the COVID-19 pandemic on alcohol use disorder symptoms: Testing interactions with polygenic risk

Objective: The purpose of this study was to test whether COVID impact interacts with genetic risk (polygenic risk score/PRS) to predict alcohol use disorder (AUD) symptoms. Method: Participants were n = 455 college students (79.6% female, 51% European Ancestry/EA, 24% African Ancestry/AFR, 25% Americas Ancestry/AMER) from a longitudinal study during the initial stage (March-May 2020) of the pandemic. Path models allowed for the examination of PRS and previously identified COVID-19 impact constructs. Results: There was a main effect of the AUD PRS on AUD symptoms within the EA group (beta: .165, p < .01). Additionally, food/housing insecurity was predictive in the AMER group (beta.295, p < .05), and greater increases in substance use were associated with AUD symptoms for EA (beta:.459, p < .001) and AMER groups (beta:.468, p < .001). Conclusions: Greater food/housing instability and increases in substance use, as well higher scores on PRS are associated with more AUD symptoms for some ancestral groups within this college sample.