TMS-EEG Reliability: Bridging the Gap to Clinical Use
arxiv(2024)
摘要
Concurrent transcranial magnetic stimulation (TMS) and electroencephalography
(EEG), or TMS-EEG, holds the potential to broaden the clinical applications of
TMS beyond its traditional role in evaluating the cortico-spinal tract and
motor cortices. TMS-evoked potentials (TEPs) have emerged as valuable tools in
clinical research, enabling the assessment of cortical excitability and
effective connectivity between cortical regions in various psychiatric and
neurological disorders and are increasingly recognized as a promising candidate
biomarker for aiding in diagnosis and prognosis. Despite the well-established
diagnostic utility of TMS, the clinical implementation of TMS-EEG has yet to
meet the necessary standards. One critical aspect that often remains
unaddressed is the reliability of TEP measurements. In this context, we outline
the crucial reliability assessments required to determine the clinical
applicability of TEPs. Firstly, we conduct a comprehensive review of the
existing literature on reliability, encompassing both theoretical and
statistical considerations. Subsequently, we present the current state of
knowledge on TEP reliability. We emphasize the specific elements of reliability
that must be incorporated to facilitate a unified, evidence-derived assessment
of TMS-EEG as a clinical tool.
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