Effect of Dietary Protein Intake from Different Sources on Maternal and Umbilical Cord Plasma Amino Acid Levels

ScopeTo assess the associations of dietary protein intake from different sources during pregnancy with maternal and umbilical cord plasma amino acid levels.Methods and resultsThe study includes 216 pregnant women and 39 newborns from the Tongji Birth Cohort in Wuhan, China. The study examines the levels of 21 amino acids in maternal and cord plasma samples using ultra-performance liquid chromatography with tandem mass spectrometry. A significant positive relationship is observed between dietary protein intake from refined grains and maternal plasma cysteine levels. Dietary protein intake from dairy products is positively associated with maternal plasma levels of sulfur amino acid (mainly cystine), but negatively associated with maternal plasma levels of glutamic acid. In addition, the study observes that pre-pregnancy body mass index and parity may be potential determinants of maternal plasma amino acid levels, whereas a history of passive smoking during pregnancy is an important factor influencing cord plasma amino acid levels.ConclusionsThese findings suggest that dietary protein intakes from specific sources during pregnancy may affect maternal plasma levels of amino acids. This study includes 216 pregnant women and 39 newborns from the Tongji Birth Cohort in Wuhan. The aims are to assess the effects of dietary protein intake from different sources and characteristics of demographics and lifestyles on maternal and umbilical cord plasma amino acid levels. image