Application of Protein Crystallography and Machine Learning Data for the Development of a Peptide Vaccine against African Swine Fever
Crystallography Reports(2023)
摘要
The genome of African swine fever (ASF) has been analyzed, and a protein that can serve an immunogen has been identified. A water-soluble fragment of this protein is shown (by the molecular dynamics) to be stable in an aqueous saline solution. Immunomodeling has shown that this fragment causes a cellular response and, therefore, may serve a vaccine prototype.
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