Galectin-3 and cancer immunotherapy: a glycobiological rationale to overcome tumor immune escape
Journal of Experimental & Clinical Cancer Research(2024)
Abstract
Immunotherapy with checkpoint inhibitors (ICIs) has radically changed the landscape of therapeutic opportunities in oncology, but much still needs to be understood from a mechanistic point of view. There is space for further improving tumors’ response to ICIs, as supported by a strong biological rationale. For this achievement a detailed analysis of tumor cell phenotype with functional dissection of the molecular interactions occurring in the TME is required. Galectin-3 is a pleiotropic tumor relevant molecule, which deserves particular attention in immuno-oncology. Due to its ability to finely modulate immune response in vivo, Galectin-3 is a potential target molecule to be considered for overcoming tumor immune escape.
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Key words
Immunotherapy, Checkpoint inhibitors,Galectin-3,Tumor microenvironment,Predictive markers of immune-response
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