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A phosphodiesterase pathway essential for lymphangiogenic growth arrest and maturation

Kari Alitalo

Developmental Cell（2024）

Cited 0|Views7
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Abstract
In developing embryos, downregulation of lymphatic endothelial proliferation is needed for maturation of lymphatic vessels into a hierarchical network. In this issue of Developmental Cell, Carlantoni discover that phosphodiesterase2A controls lymphatic endothelial growth arrest and maturation via regulation of cGMP, p38 MAP kinase, and Notch pathway.
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