Scaling Up Production of Recombinant Human Basic Fibroblast Growth Factor in an Escherichia Coli BL21(DE3) Plyss Strain and Evaluation of Its Pro-Wound Healing Efficacy

Le Li,Bingjie Yu, Yingji Lai,Siyuan Shen,Yawei Yan, Guojun Dong, Xiangyun Gao, Yanrong Cao, Caojie Ge, Liqin Zhu, Huan Liu,Shanhui Tao,Zhiang Yao,Shijun Li,Xiaojie Wang,Qi Hui

FRONTIERS IN PHARMACOLOGY（2024）

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Key words

hbFGF,Escherichia coli BL21(DE3) plysS,optimized production,500-L fermentation,purification,wound healing

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