Suppression of Sleeping Beauty-induced Gliomagenicity in Ts1Cje Mice, a Model of Down Syndrome

Background/Aim: Individuals with Down syndrome
(DS), attributed to triplication of human chromosome 21
(Hsa21), exhibit a reduced incidence of solid tumors. However,
the prevalence of glioblastoma among individuals with DS
remains a contentious issue in epidemiological studies.
Therefore, this study examined the gliomagenicity in Ts1Cje
mice, a murine model of DS. Materials and Methods: We
employed the Sleeping Beauty transposon system for the
integration of human oncogenes into cells of the subventricular
zone of neonatal mice. Results: Notably, Sleeping Beautymediated
de novo murine gliomagenesis was significantly
suppressed in Ts1Cje mice compared to wild-type mice. In
glioblastomas of Ts1je mice, we observed an augmented
presence of M1-polarized tumor-associated macrophages and
microglia, known for their anti-tumor efficacy in the early
stage of tumor development. Conclusion: Our findings in a
mouse model of DS offer novel perspectives on the diminished
gliomagenicity observed in individuals with DS