Differential regulation of T‐cell dependent and T‐cell independent antibody responses through arginine methyltransferase PRMT 1 in vivo
FEBS Letters(2016)
Abstract
Protein arginine methyltransferase 1 ( PRMT 1), a major PRMT in mammalian cells, has been shown to play a crucial role in multiple biological functions in vitro . To explore the role of PRMT 1 in B cells in vivo , we generated B cell‐specific PRMT 1‐deficient ( Prmt1 −/− ) mice using a Cre‐loxP system. Prmt1 −/− mice showed a defect in B‐cell development with diminished levels of serum antibodies. Antibody responses in Prmt1 −/− mice were absent after stimulation with the type 2 T cell‐independent antigen NP ‐Ficoll but intact after stimulation with the T cell‐dependent antigen NP ‐ OVA . Our findings comprise the first evidence showing that PRMT 1 is necessary for lymphocyte functions in vivo .
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Key words
arginine methyltransferase prmt1,independent antibody responses,differential regulation,t-cell,t-cell
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