Modelling and Simulation of Genomic Sequencing Platform Operations.

This paper focuses on the healthcare application field of Genomic Sequencing and addresses the challenge of efficient organization and ramp-up of sequencing platforms. High-throughput sequencing platforms are currently in an industrial prototyping phase in France for large national deployment afterwards. In the current state of our knowledge, there is no scientifically established generic model nor decision-making support at the operational level which could guide the medical authorities in designing organizational rules, then managing the deployment of such platforms at the national level. After analyzing the state of the art, a simulation model of a genome sequencing platform is presented, then used as a decision-making support to manage a ramp-up situation for an application case of a French sequencing platform. These first results are discussed, together with the perspective to develop a generic model and decision-aid approach.