Mouse Models of α-Synucleinopathy and Lewy Pathology

Samuel Barbieri,Katja Hofele,Karl‐Heinz Wiederhold,A. Probst,Claudia Mistl,Simone Danner,Serge Kauffmann,Bernd Sommer,Will Spooren,Markus Tolnay,Graeme Bilbe,Herman van der Putten

Advances in Experimental Medicine and Biology（2001）

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摘要

Idiopathic Parkinson’s Disease (PD), dementia with Lewy bodies (DLB), and a Lewy Body variant of Alzheimer’s Disease (LBVAD) are characterized pathologically by proteinaceous inclusions in neurons commonly referred to as Lewy pathology inpost mortembrain tissue samples1–6. The inclusions occur in the dystrophic (Lewy) neurites that constitute an important part of the pathology of PD and DLB4–6, in neuronal perikarya (Lewy bodies), and occasionally extracellularly11.

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mouse,pathology

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