Alkylation of Phenols with 4,6-Di- tert -butyl-3-methoxymethylcatechol. Antiradical Activity of Sterically Hindered Catecholphenols

A series of sterically hindered catecholphenols was synthesized by the reaction 4,6-di- tert -butyl-3-methoxymethylcatechol with resorcinol, 4,6-di- tert -butylresorcinol, orcinol, 3,5-dimethoxyphenol, α- and β-naphthol. The structure of the obtained compounds was proved by NMR, IR and mass spectroscopy. The structure of 4,6-di- tert -butyl-3-[(2-hydroxynaphthalen-1-yl)methyl]benzene-1,2-diol was determined by single-crystal X-ray diffraction. The radical scavenging of obtained compounds were determined using 2,2-diphenyl-1-picrylhydrazyl radical test.