Synthesis and Anti- Vibrio Activity of Gallic Acid Derivatives Containing Acyl Thiourea Phenol

series of gallic acid derivatives containing acyl thiourea phenol were designed and synthesized with gallic acid as a raw material, and their antibacterial activities were evaluated: the synthesized acyl thiourea phenol derivatives of gallic acid had certain anti- Vibrio activity at 1 mg/mL; compounds 4a and 4c showed good inhibitory activity against Vibrio harveyi , MIC was 0.0156 mg/mL; compound 4f also showed certain anti- Vibrio cholerae activity, MIC was 0.0313 mg/mL; compound 4g showed anti- Vibrio parahaemolyticus activity, MIC was 0.0156 mg/mL; this series of compounds has poor inhibitory activity against Vibrio vulnificus. Only compounds 4a , 4c , 4e , 4g , and 4j have weak inhibitory activity against Vibrio vulnificus , with MIC of 0.125 mg/mL.