Impact of Therapy Sequence on Survival Outcomes Among Patients with Relapsed or Refractory Mature T and NK Cell Neoplasms: A Global Retrospective Cohort Study

Mark N. Sorial,Min Jung Koh,Leora Boussi,Jessy Xinyi Han,Luke Peng,Ijeoma Julie Eche-Ugwu, Rui Duan,Matthew M. Lei,Eliana Miranda,Carlos Chiattone,Robert Stuver,Steven M. Horwitz, Maria J. Fernandez Turizo, Sean McCabe,Mwanasha Hamuza Merrill,Eric Jacobsen,Jin Seok Kim,Yu Ri Kim,Jae Yong Cho,Hasmukh Jain,Manju Sengar,Thomas Eipe,Tanuja Shet,Shambhavi Singh,Uvette Lou, Hesham Raghib, Judith Gabler,Min Ji Koh,Carrie Van der Weyden,Miles Prince,Ramzi Hamouche, Tinatin Muradashvili,Francine M. Foss,Marianna Gentilini,Beatrice Casadei, Pier Luigi Zinzani,Takeshi Okatani,Noriaki Yoshida,Sang Eun Yoon,Won Seog Kim, Girisha Panchoo, Zainab Mohamed,Estelle Verburgh, Jackielyn Cuenca Alturas, Mubarak Al Mansour, Josie Ford,Martina Manni,Massimo Federico,Owen A. O'Connor,Maria Elena Cabrera,Enrica Marchi, Changyu Shen, Devavrat Shah,Salvia Jain

BLOOD（2023）

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Abstract

Despite evolution of therapeutic strategies, there is no universal standard of care for relapsed or refractory (RR) mature T and NK-cell neoplasms (TNKL). Most patients receive multiple lines of therapy and cycle through many available options. 1-3 There is no data to inform optimal therapy sequence, however emerging data suggest that exposure to epigenetic modifiers (EM) can sensitize tumors to other therapies. 4-6 Here we report results of comparative analyses assessing survival outcomes based on therapy sequence using a global RR TNKL patient cohort with data from 15 centers across 6 continents.

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