Panda Sign: The Defining Feature of Wilson’s Disease

Wilson’s disease is an autosomal recessive disorder caused by a mutation of the Wilson's (global) disease (ATP7B) protein produced by chromosome 13 [1]. It manifests as an inability to excrete copper in bile, leading to copper deposition in the liver, brain, and other organs. Clinical signs and symptoms include liver dysfunction and neuropsychiatric disorders [2]. While copper accumulation primarily occurs in the basal ganglia, it can affect all parts of the brain. Magnetic Resonance Imaging (MRI) is an effective tool for assessing disease severity and treatment response [3].