Prioritizing TWAS Genetic Biomarkers for Melanoma Metastasis via Gene Expression Profiling^*

The development of novel therapeutic approaches that target gene alterations in melanoma cells remains an area of active research. This study prioritized ten genes out of 76 genes - associated with melanoma through a transcriptome-wide association study (TWAS). We investigated the potential of the identified ten genes in prognosis of metastasis in melanoma patients.Clinical Relevance: Our findings have clinical implications for melanoma treatment strategies. Targeted therapies that specifically address the dysregulation of our 10 genes may hold promise in preventing or slowing melanoma metastasis.