Removing Scattered Light in Biomedical Images via an Unsupervised Deep Neural Network

Scattered light is unavoidable during biomedical imaging, leading to downgraded images. Removing such scattered light, however, is challenging, because the imaging objects are complex and the light path is complicated. In this paper, we propose to use deep learning methods to computationally remove such scattered light. Inspired by the dehazing methods for natural images, we first developed a novel mathematical model for biomedical images. Then, we developed a deep neural network method to solve this model. Our network simultaneously estimates the clear image and the scattered light. Several experiments are conducted to confirm the network’s effectiveness and efficiency.