Astragaloside IV alleviates macrophage senescence and d-galactose-induced bone loss in mice through STING/NF-κB pathway

Muzhe Li, Yuanyuan Niu, Linkun Tian,Tianchi Zhang, Shijie Zhou,Lining Wang,Jie Sun,Taxi Wumiti,Zhiwei Chen, Qinfeng Zhou,Yong Ma,Yang Guo

International Immunopharmacology（2024）

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摘要

•AS-IV impedes macrophage senescence and promotes osteogenic differentiation of BMSCs through the modulation of STING/NF-κB.•AS-IV treatment ameliorated macrophage senescence, abnormal bone microstructure, and bone mass loss in a mouse model of SOP.

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关键词

AS-IV,Macrophage senescence,SOP,STING,NF-κB pathway

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