Mixed Connective Tissue Disease with Bilateral Erythematous Palpebral Oedema and Targetoid Skin Lesions

Mixed connective tissue disease (MCTD) is a rare connective tissue disease with an autoimmune background. Clinically, it is characterised by manifestations shared with other connective tissue diseases; systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and polymyositis/dermatomyositis [1, 2]. High titres of distinct serum autoantibodies to the U1 small nuclear ribonucleoprotein (RNP) are characteristic of MCTD. Several skin manifestations of MCTD are known, including Raynaud's phenomenon, [...]