Genome-wide DNA methylation analysis of cannabis use disorder in a veteran cohort enriched for posttraumatic stress disorder

Melanie E. Garrett,Michelle F. Dennis,Kyle J. Bourassa,Michael A. Hauser,Nathan A. Kimbrel,Jean C. Beckham,Allison E. Ashley-Koch

Psychiatry Research（2024）

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摘要

•Four CpG sites were associated with cannabis use disorder in a cohort of veterans•Veterans with CUD and PTSD had significantly lower DNAm at two of these CpG sites•AHRR cg05575921 partially mediates the relationship between CUD and mood disorders

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关键词

Epigenetics,Cannabis use disorder,PTSD,EWAS,AHRR,mediation

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