Exploring the Untapped Potential of Marine Sponge Compounds as Anticancer Agents against ERα of Breast Cancer

•Marine sponge derivatives are studied as an anticancer agent for breast cancer cells.•Residues involved in this interaction are characterized using molecular docking studies.•Molecular dynamic (MD) simulations over 120 nanoseconds were run.•MM/PBSA analysis are studied to mimic complex stability in aqueous environment.•Importantly, several screening filters were applied by assesing their ADMET properties.•The current in-silico findings are highly ecourging for in-vitro and/or wet lab analysis.