Inhibitory impact of cinobufagin in triple-negative breast cancer metastasis: involvements of macrophage reprogramming through upregulated MME and inactivated FAK/STAT3 signaling

Zhaohui Zhu, Hanlu Wang,Xu Qian, Meiling Xue,Aijun Sun,Yifei Yin,Jinhai Tang,Jian Zhang

Clinical Breast Cancer（2024）

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摘要

•CBG treatment suppresses metastasis of TNBC cells in mice.•CBG enhances MME expression to induce M1 polarization of TAMs.•MME silencing increases M2 TAM populations and enhances mobility of TNBC cells.•MME inactivates the FAK/STAT3 signaling pathway.•Antagonist of FAK/STAT3 reprograms TAM phenotype and suppresses TNBC cell metastasis.

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关键词

Cinobufagin,MME,FAK/STAT3 signaling pathway,Tumor-associated macrophages,Triple-negative breast cancer

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