Development of an Optimized Process for the Liver-Targeted Triantennary N-Acetylgalactosamine Ligand

Joseph T. Kim,Andrew K. Mcpherson,Andrew A. Rodriguez,Lijian Chen, Yee Fung Lu, Nick Moskalev,Sunil K. Upadhyay, Caroline Green, Miranda Whetsell, Jiang Xiang-Rong, Alexander Trofimov,Francis Ring, Ashley Davalos,Christopher M. Gabriel,Phil Olsen

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2023）

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关键词

antisense oligonucleotide (ASO),asialoglycoproteinreceptor (ASGPR),GalNAc conjugation,critical impurities,risk/gap assessment,design of experiments (DoE)

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