The importance of second-trimester AFP and preconception TSH levels for predicting the severity of proteinuria in patients with preeclampsia

Objective: This study aimed to investigate the relationships between preconception thyroid stimulating hormone (TSH) and thyroxine (T4) levels, as well as second-trimester alpha-fetoprotein (AFP) levels, and the severity of proteinuria in 24-hour urine samples from patients with preeclampsia. Method: This retrospective analysis focused on preeclampsia patients categorized by proteinuria in 24-hour urine. Inclusion criteria involved patients aged 20-44 with singleton pregnancies diagnosed with preeclampsia and delivery after 20 weeks of gestation. Patients were divided into mild (0.3 to