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Effect of andrographolide and deep eutectic solvent extracts of Andrographis paniculata on human coronavirus organ culture 43 (HCoV-OC43)

Jukrapun Komaikul,Sasiporn Ruangdachsuwan,Duangnapa Wanlayaporn,Somnuek Palabodeewat,Surat Punyahathaikul,Theeraporn Churod,Rattanathorn Choonong,Tharita Kitisripanya

Phytomedicine（2023）

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Abstract
•Andrographolide and A. paniculata extracts inhibit HCoV-OC43 replication.•Malic acid or citric acid improve DES capability for andrographolide extraction.•Moderately strong relationship between antiviral activity and andrographolide content.•A. paniculata quality in terms of anti-HCoV-OC43 activity.
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Key words
Andrographis,Coronavirus,Antiviral activity,Herbal medicine,Deep eutectic solvent,Plant extract
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