Analysis of NETs (neutrophil extracellular traps) in coronary thrombus and peripheral blood of patients with ST-segment elevation myocardial infarction

Ana Blasco,Axel Rosell,Raquel Castejon, Maria Jose Coronadof,Ana Royuela,Elvira Ramil, Silvia Elorza,Charlotte Thalin,Paloma Martin, Basilio Angulo, Beatriz Rascon,Sergio Garcia-Gomez, Inuntze Zabala,Javier Ortega,Lorenzo Silva,Carmen Bellas

THROMBOSIS RESEARCH（2024）

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摘要

•Neutrophil extracellular traps (NET) formation in coronary thrombosis is linked to poor prognosis.•A comparison of tissue NETs and citrullinated histone 3 (H3Cit) in serum by standardized methods•No correlation was found between NETs in thrombi and levels of H3Cit or other inflammatory markers in serum.•NET formation in coronary thrombosis would be a local phenomenon not detectable in the bloodstream.

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