External Validation of the PE-SARD Risk Score for Predicting Early Bleeding in Acute Pulmonary Embolism in the RIETE Registry
Thrombosis research(2024)
摘要
Introduction: The PE-SARD score (syncope, anemia, renal dysfunction) was developed to predict the risk of major bleeding in the acute phase of pulmonary embolism (PE). Methods: We analyzed data from 50,686 patients with acute PE included in the RIETE registry to externally validate the PE-SARD score. We calculated the overall reliability of the PE-SARD score, as well as discrimination and calibration for predicting the risk of major bleeding at 30 days. The performance of PE-SARD was compared to the BACS and PE -CH models. Results: During the first 30 days, 640 patients (1.3 %) had a major bleeding event. The incidence of major bleeding within 30 days was 0.6 % in the PE-SARD-defined low -risk group, 1.5 % in the intermediate -risk group, and 2.5 % in the high -risk group, for an OR of 2.22 (95 % CI, 2.02-2.43) for the intermediate -risk group (vs lowrisk group), and 3.94 for the high -risk group (vs low -risk group). The corresponding sensitivity was 81.1 % (intermediate/high vs low risk), and specificity was 85.9 % (95 % CI, 85.8-86.1) (low/intermediate vs high risk). The applicability of PE-SARD was consistent across clinically relevant patient subgroups and over shorter time periods of follow-up (i.e., 3 and 7 days). The C -index was 0.654 and calibration was excellent. The PE-SARD bleeding score improved the major bleeding risk prediction compared with the BACS and PE -CH scores. Conclusions: The PE-SARD score identifies PE patients with a higher risk of bleeding, which could assist providers for potentially adjusting PE management, in a framework of shared decision -making with individual patients.
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关键词
Pulmonary embolism,Bleeding,Score,External validation
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