A LC-MS/MS method for the simultaneous quantitative determination of aldosterone, its precursor 18-hydroxycorticosterone and its metabolite tetrahydroaldosterone in human urine

Haohang Dong,Bin Hu, Wei Chen, Liping Wang,Huiying Sun, Jianfeng Zhou, Jianchun Chen,Baorong Chen,Zhenxia Du

Journal of Chromatography B（2024）

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摘要

•We developed and validated a LC-MS/MS method capable of simultaneously quantifying ALD (free),18-OHB and TH-ALD in urine for the first time. Our study provides a reference for the use of new biomarkers for the diagnosis of primary aldosteronism.

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关键词

Primary aldosteronism,Aldosterone (free),18-hydroxycorticosterone,Tetrahydroaldosterone,Liquid chromatography-tandem mass spectrometry

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