Utility of the Paris system (TPS) for upper urinary tract cytopathology: correlation with histology follow-up and UroVysion fluorescence in situ hybridization analysis (FISH)

•The Paris system (TPS) for reporting urinary cytology is a standardized, evidence-based reporting system and particularly focuses on the detection of high grade urothelial carcinoma. However, limited studies on the utility of TPS in upper urinary tract (UUT) lesions and follow-up histology of cases with abnormal cytology are available.•In this 5-year retrospective study, we described our experience of upper urinary tract cytology specimens with cytologic interpretation using TPS, and further correlated with histology findings and UroVysion FISH test.•A total of 83 patients had concurrent or subsequent histologic specimens and cyto-histologic discrepancy was seen in 9 cases (10.8%). The sensitivity and specificity using TPS criteria for detecting HGUC were 82% and 92%, respectively.•UroVysion FISH was performed in 21 patients with atypical cytologic findings. The sensitivity and specificity of UroVysion for detecting HGUC of UUT was 75% and 86%, respectively.