The role of neurotrophin polymorphisms and susceptibility to neural damage in leprosy

Karina Talita de Oliveira Santana Jorge, Marina Pimenta Braga, Rodrigo Anselmo Cazzaniga,Camilla Natália Oliveira Santos,Mauro Martins Teixeira,Karina Braga Gomes, Amélia Maria Ribeiro de Jesus,Frederico Marianetti Soriani

International Journal of Infectious Diseases（2024）

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摘要

•rs11030099 of BDNF neurotrophin is associated with nerve damage in leprosy patients•rs11030099 is not associated with BDNF serum level•rs11030099 is located in a miR-26a binding region•miR-26 and rs11030099 may be acting synergistically•Other investigated SNPs of neurotrophins are not associated with leprosy phenotypes

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BDNF,polymorphism,SNP,neurotrophins,leprosy

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