Mitochondrial genomes revisited: why do different lineages retain different genes?
BMC Biology(2024)
Abstract
The mitochondria contain their own genome derived from an alphaproteobacterial endosymbiont. From thousands of protein-coding genes originally encoded by their ancestor, only between 1 and about 70 are encoded on extant mitochondrial genomes (mitogenomes). Thanks to a dramatically increasing number of sequenced and annotated mitogenomes a coherent picture of why some genes were lost, or relocated to the nucleus, is emerging. In this review, we describe the characteristics of mitochondria-to-nucleus gene transfer and the resulting varied content of mitogenomes across eukaryotes. We introduce a ‘burst-upon-drift’ model to best explain nuclear-mitochondrial population genetics with flares of transfer due to genetic drift.
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Key words
CoRR hypothesis,Evolutionary cell biology,Endosymbiont gene transfer,Mitochondrial DNA,Mitochondrial evolution,Mitochondrial mutation rates
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