Comprehensive greenness evaluation of the reported chromatographic methods for aldehydes determination as clinical biomarkers and food quality indicators

Aldehydes are carbonyl compounds that are highly reactive and extensively abundant in nature. Aldehydes are biomarkers for oxidative stress-linked disorders since they are formed as a result of oxidative processes. Aldehydes may occur in food as a result of food processing or degradation, and their level has been utilized as a guide of food quality level. Therefore, aldehydes are identified in biological and food samples as illness indicators and as by-products of food manufacturing, respectively. Among analytical methodologies, chromatographic methods are the most used for the simultaneous determination of various aldehydes. However, chromatographic methods consume a lot of harmful organic solvents and reagents. Hence, herein, a comprehensive greenness evaluation of the reported chromatographic methods for aldehydes has been conducted using AGREE—Analytical GREEnness Metric. This review helps to recommend those methods that are eco-friendly to be further used for the assay of aldehydes in versatile samples.