Targeting thrombospondin-2 retards liver fibrosis by inhibiting TLR4-FAK/TGF-β signaling

Ning Zhang,Xiaoning Wu,Wen Zhang,Yameng Sun,Xuzhen Yan,Anjian Xu,Qi Han,Aiting Yang,Hong You,Wei Chen

JHEP Reports（2024）

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摘要

•THBS2 expression depends on liver fibrosis severity and decreases in regression.•Thbs2 inhibition in HSCs ameliorates intrahepatic inflammation and liver fibrosis.•Thbs2 inhibition in HSCs suppresses MASH progression.•THBS2 regulates the activity of HSCs via mediating the TLR4-TGF-β/FAK axis.•Extracellular THBS2 directly interacts with TLR4 on HSCs as a dimer type.

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关键词

extracellular matrix,metabolic dysfunction-associated steatohepatitis,smooth muscle α-actin promoter,myofibroblast tropism,cirrhosis

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