Undescribed sesquiterpene-diterpene heterodimers from the fruits of Aphanamixis polystachya selectively modulate inflammatory markers in RAW 264.7 cells
PHYTOCHEMISTRY(2024)
Abstract
Aphanapolystachones A-C (1-3), three undescribed sesquiterpene-diterpene heterodimers, were obtained from the fruits of Aphanamixis polystachya. Their structures and absolute configurations were identified by extensive analysis of HR-ESI-MS, NMR, experimental and TD-DFT calculated ECD spectra. The biosynthetic pathway of them was also proposed, which is produced by key intermolecular Diels-Alder [4 + 2]-cycloaddition reaction between a guaiane sesquiterpene and an acyclic diterpene. Compounds 1-3 inhibited NO production in LPS activated RAW 264.7 cells with the IC50 values of 1.7 +/- 0.2, 3.0 +/- 0.3, 5.3 +/- 0.3 mu M, respectively, lower than that of the positive control L-NMMA (31.5 +/- 2.6 mu M). In addition, compounds 1-3 significantly reduced IL -6 secretion at diluted concentration of 0.4 mu M.
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Key words
Aphanamixis polystachya,Meliaceae,Aphanapolystachone,Sesquiterpene-diterpene heterodimer,Anti-inflammatory activity
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