Design, Synthesis, and Evolution of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors: P1-Argininal Derivatives Incorporating P3-P4 Lactam Sulfonamide Moieties

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTDesign, Synthesis, and Evolution of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors: P1-Argininal Derivatives Incorporating P3-P4 Lactam Sulfonamide Moieties 1J. Edward Semple, David C. Rowley, Terence K. Brunck, Theresa Ha-Uong, Nathaniel K. Minami, Timothy D. Owens, Susan Y. Tamura, Erick A. Goldman, Daniel V. Siev, Robert J. Ardecky, Stephen H. Carpenter, Yu Ge, Brigitte M. Richard, Thomas G. Nolan, Kjell Håkanson, Al Tulinsky, Ruth F. Nutt, and William C. RipkaView Author Information Corvas International, Inc., 3030 Science Park Road, San Diego, California 92121-1102, and Department of Chemistry, Michigan State University, East Lansing, Michigan 48824-1322 Cite this: J. Med. Chem. 1996, 39, 23, 4531–4536Publication Date (Web):November 8, 1996Publication History Received5 August 1996Published online8 November 1996Published inissue 1 January 1996https://doi.org/10.1021/jm960572nCopyright © 1996 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1005Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (348 KB) Get e-AlertscloseSUBJECTS:Amides,Inhibitors,Peptides and proteins,Selectivity,Sulfones Get e-Alerts