MicroRNA-18a regulates the Pyroptosis, Apoptosis, and Necroptosis (PANoptosis) of osteoblasts induced by tumor necrosis factor-α via hypoxia-inducible factor-1α

•miR-18a-5p was suppressed in TNF-α induced inflammatory condition.•Overexpressing of miR-18a or deregulating of HIF1-α and NLRP3 could reverse the effect of TNF-α.•TNF-α negatively regulates osteoblasts via the 18a/HIF1-α/NLRP3 pathway.•miR-18a could attenuate inflammation and PANoptosis, then promote the healing of infected bone defects in vivo.