In-silico Analysis of Hemodynamic Indicators in Idealized Stented Coronary Arteries for Varying Stent Indentation
arxiv(2024)
摘要
In this work, we investigate the effects of stent indentation on hemodynamic
indicators in stented coronary arteries. Our aim is to assess in-silico risk
factors for in-stent restenosis (ISR) and thrombosis after stent implantation.
The proposed model is applied to an idealized artery with Xience V stent for
four indentation percentages and three mesh refinements. We analyze the
patterns of hemodynamic indicators arising from different stent indentations
and propose an empirical frequency analysis of time-averaged WSS (TAWSS),
oscillatory shear index (OSI), and relative residence time (RRT). We observe
that higher indentations display higher frequency of critically low TAWSS and
non-physiological OSI and RRT. Furthermore, an appropriate mesh refinement is
needed for accurate representation of hemodynamics in the stent vicinity. The
results provide physics-based evidence for the correlation between high
indentation and ISR.
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