Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176

Mickey Konings,Bert Gerrits van den Ende, Mirthe W. J. Raats,Ahmed Hassan Fahal,Wendy W. J. van de Sande,Ferry Hagen

Mycopathologia（2024）

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摘要

Madurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M. fahalii type-strain CBS 129176 genome assembly and annotation to identify a glutamic acid insert near the azole-binding pocket in the Cyp51A protein.

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关键词

Madurella mycetomatis,Madurella fahalii,Nanopore sequencing,De novo genome assembly,Decreased itraconazole susceptibility

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