Current Status and Treatment of Rapid Cycling Bipolar Disorder

Background: Rapid cycling (RC) at least 4 recurrent episodes per year in bipolar disorder (BD) has been recognized since the 1970s. We now comment on our recent review of the topic and extensive RC analysis in a large clinical cohort, emphasizing therapeutics research. Comments: Prevalence of RC -BD averages 36% for any year versus 22% in the preceding year. Rapid cycling is not a consistent feature over many years, although average long-term, annual recurrence rates are greater in RC-BD patients. Risk of RC maybe somewhat greater among women and with older ages. It is also associated with cyclothymic temperament, prominent depression, and mood -switching with antidepressant treatment and is associated with increased suicidal risk. Treatment of individual episodes in RC -BD and effective long-term prevention remain inadequately studied, although antidepressant treatment can worsen RC. Some research supports treatment with aripiprazole, lamotrigine, and lithium, and interest in second -generation antipsychotics is emerging. All such options are used in various inadequately evaluated combinations. Conclusions: Rapid cycling is prevalent among BD patients but seems to vary in risk over time without evidence of progressive worsening. Treatment of acute episodes in RC -BD patients and effective long-term preventive management require much more intensive investigation.