Resistant hypertension: Diagnosis, evaluation, and treatment practical approach

•BP is uncontrolled despite the use of three drugs at optimal or best tolerated doses.•The estimated prevalence of true RH is 5 % when strict criteria are applied.•Rule out pseudo-resistance before diagnosing true drug resistance.•Consider mineralocorticoid receptor antagonists as drug number four.•Renal denervation can be considered as a treatment option in some patients.