Symbol letters of Feynman integrals from Gram determinants

Symbol letters are crucial for analytically calculating Feynman integrals in terms of iterated integrals. We present a novel method to construct the symbol letters for a given integral family without prior knowledge of the canonical differential equations. We provide a program package implementing our algorithm, and demonstrate its effectiveness in solving non-trivial problems with multiple loops and legs. Using our method, we successfully bootstrap the canonical differential equations for a two-loop five-point family with two external masses and for a three-loop four-point family with two external masses, which were previously unknown in the literature. We anticipate that our method can be applied to a wide range of cutting-edge calculations in the future.