Transcriptionally Active Defective HIV-1 Proviruses and Their Association With Immunological Nonresponse to Antiretroviral Therapy
JOURNAL OF INFECTIOUS DISEASES(2024)
Abstract
A subset of antiretroviral therapy-treated persons with human immunodeficiency virus (HIV), referred to as immunological nonresponders (INRs), fails to normalize CD4(+) T-cell numbers. In a case-control study involving 26 INRs (CD4 < 250 cells/mu L) and 25 immunological responders (IRs; CD4 >= 250 cells/mu L), we evaluated the potential contribution of transcriptionally competent defective HIV-1 proviruses to poor CD4(+ )T-cell recovery. Compared to the responders, the INRs had higher levels of cell-associated HIV RNA (P = .034) and higher percentages of HLA-DR+ CD4(+ )T cells (P < .001). While not encoding replication-competent viruses, the RNA transcripts frequently encoded HIV-1 Gag-p17 and Nef proteins. These transcripts and/or resulting proteins may activate pathway(s) leading to the immunological nonresponse phenotype.
MoreTranslated text
Key words
HIV immunological nonresponse,defective HIV-1 proviruses,transcription
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined