Assembly of Isoxazolyl Vinyl Silanes via Palladium-Catalyzed Sequential Oxygenation/Vinylation of Ynone Oximes.
Chemistry, an Asian journal(2024)
Abstract
A palladium-catalyzed sequential oxygenation/ vinylation for the assembly of synthetically valuable isoxazolyl vinyl silane derivative has been accomplished. Easily accessible ynone oximes, and readily available vinylsilane agents were used as the reaction starting materials This protocol features broad substrate scope, good functional group tolerance, and good step- and atom-economy. Remarkably, this approach provides a new channel for the construction of structurally diverse isoxazolyl-containing vinylsilanes with high complexity, showing a promising application in synthetic and pharmaceutical chemistry.
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