Exploring optimization algorithms for establishing patient-based real-time quality control models

•Evolution Algorithms cansignificantly decrease the computational time required for hyperparameter optimization in patient-based real-time quality control models.•More efficient optimization approaches provide the groundwork for advanced PBRTQC algorithms like regression-adjusted real-time quality control.•The use of efficient optimization hyperparameters may enhance the automation of PBRTQC model construction and aid in future PBRTQC model deployment in the real world.