Extracellular derivatives for bone metabolism

•The sources of producing extracellular derivatives are extensive, that together affect bone growth and metabolism.•Extracellular derivatives act as targeted drug carriers and offer a fresh perspective in the treatment landscape.•Orthopedics witnessed innovative approaches centered around extracellular vesicles, revealing their promise in bone healing and regeneration.•The exact mechanisms by which extracellular derivatives influence bone health are complex and subtle, marking an exciting area of exploration and study.•Extracellular derivatives have attractive potential for organoid applications, and their combination could usher in a new era of organoid-based research and therapy.