Advances in the study of antisense long-stranded non-coding RNAs in tumors (Review)
INTERNATIONAL JOURNAL OF ONCOLOGY(2024)
摘要
Long-stranded non-coding RNAs (lncRNAs) are RNAs that consist of >200 nucleotides. The majority of lncRNAs do not encode proteins but have been revealed to mediate a variety of important physiological functions. Antisense-lncRNAs (AS-lncRNAs) are transcribed from the opposite strand of a protein or non-protein coding gene as part of the antisense strand of the coding gene. AS-lncRNAs can serve an important role in the tumorigenesis, prognosis, metastasis and drug resistance of a number of malignancies. This has been reported to be exerted through various mechanisms, such as endogenous competition, promoter interactions, direct interactions with mRNAs, acting as 'scaffolds' to regulate mRNA half-life, interactions with 5-untranslated regions and regulation of sense mRNAs. AS-lncRNAs have been found to either inhibit or promote tumor aggressiveness by regulating cell proliferation, energy metabolism, inflammation, inflammatory-carcinoma transformation, invasion, migration and angiogenesis. In addition, accumulating evidence has documented that AS-lncRNAs can regulate tumor therapy resistance. Therefore, targeting aberrantly expressed AS-lncRNAs for cancer treatment may prove to be a promising approach to reverse therapy resistance. In the present review, research advances on the role of AS-lncRNAs in tumor occurrence and development were summarized, with the aim of providing novel ideas for further research in this field.
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关键词
antisense long-stranded non-coding RNAs,tumor,carcinoma,cancer,therapy resistance
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