CD371+ pediatric B-cell acute lymphoblastic leukemia: propensity to lineage switch and slow early response to treatment

Barbara Buldini,Elena Varotto,Margarita Maurer-Granofszky,Giuseppe Gaipa,Angela Schumich,Monika Brüggemann,Ester Mejstrikova,Giovanni Cazzaniga,Ondrej Hrusak,Monika Szczepanowski,Pamela Scarparo,Martin Zimmermann, Sabine Strehl, Dagmar Schinnerl,Marketa Zaliova,Leonid Karawajew,Jean-Pierre Bourquin,Tamar Feuerstein,Gunnar Cario,Julia Alten

Blood（2024）

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摘要

•Pediatric CD371-positive B-precursor acute lymphoblastic leukemia shows transient lineage switch and slow early response to treatment.•Accurate immunophenotypic identification of lineage switch is mandatory to properly assess MRD by flow-cytometry.

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